Endocrine Abstracts

Short stature is a frequent finding among patients with beta-thalassemia major, with a major impact on the quality of life and a multifactorial aetiology.Aim: To study the relationship between growth retardation of thalassemic patients and associated sistemic conditions and endocrine complications.Subjects and methods: Cross-sectional study on 59 patients with βthalassemia major who did not reach their final height, with a mea...

Aim: The aim of the study was to evaluate the relation between anthropometric measurements, plasma biomarkers of inflammation, metabolic and adipokines pattern and the presence of severe steatosis, in a group of patients with morbid obesity.Materials and methods: We evaluated a group of 40 patients (25 F, 15 M) with morbid obesity and indication for bariatric surgery. Anthropometric measurements (waist circumference, BMI determination) were performed and...

The objective of the study was to evaluate the prevalence of secreting profile among a series of subjects with incidental discovered adrenal tumors. Subjects. 139 subjects (112 women and 27 men) diagnosed with adrenal tumors between 2010 and 2015 in our department.Methods: Medical records were retrospectively analysed for demographic data, routine tests, specific adrenal hormones measurements, associated diseases.Results: Regarding...

Background: The occurrence of multiple endocrine tumors in the same patient is not always typical and cannot always be classified into a multiple endocrine neoplasia (MEN) type, McCune-Albright syndrome or the Carney complex. Schwannomas are mesenchymal tumors that originate from Schwann cells of peripheral nerve fibers that can associate in some syndromes. 90% cases are benign, involving usually the head, neck and extremities. They are rare in the retroperitoneal region (1&#1...

Introduction: Higher body mass index (BMI) has been associated with adverse renal outcomes, including chronic kidney disease (CKD), progression to end-stage renal disease (ESRD), nephrolithiasis and renal cell cancer. Several studies have shown that weight loss following bariatric surgery has a positive effect on kidney function, mediated by a reduction in proteinuria, glomerular hyperfiltration and improvements in blood pressure and insulin resistance. The aim of this study w...

Introduction: Obesity, defined as a BMI ≥30 kg/m2, is the most common chronic metabolic disease in the world and its prevalence has strongly increased. Obesity is associated with multiple comorbidities, including cardiovascular disease, hypertension, insulin resistance, dyslipidemia, type 2 diabetes, sleep apnea and certain cancers. Bariatric surgery is the most effective treatment for severe obesity and produces dramatic and durable weight loss. The ...

Introduction: The term disorder of sexual development (DSD) refers to a congenital condition characterised by a discordance in the development of chromosomal, gonadal and anatomical sex. The inborn errors of metabolism in these disorders due to genetic mutations lead to anomalous genitalia.Case report: A 16-year-old girl without significant family history was referred to our department for primary amenorrhea. The physical examination revealed: height of ...

Introduction: Rheumatoid arthritis is an inflammatory disease characterized by joint destruction, the erosion being caused by invasion of articular cartilage by the synovial pannus. This chronic systemic disease affects approximately 0.5–1% of the adult population, occurring more often in women than in men (3:1). The etiology is thought to be multifactorial, environmental factors or infectious agents being suggested to play a role, but their contribution is yet to be defi...

Mucoepidermoid carcinomas (MECs) are the most common malignant tumors of the salivary glands. Primary thyroid MECs are extremely rare (about 0.5% of all thyroid malignancies) and, in the majority of cases, are associated with an indolent biologic potential and excellent long-term prognosis. We present the case of a 67-year-old man, with a recently growing anterior cervical mass, associating dyspnoea and fatigue. Thyroid ultrasound revealed an inhomogeneous, hypoechoic mass in ...

Introduction: Meningiomas, already one of the most frequent types of primary central nervous system tumors, have been increasing in incidence in the past decade. Considering their location and histologic particularities, radiation therapy (RT), alone or in combination with neurosurgery, is often necessary and can have a negative impact on adjacent structures such as the pituitary gland. More studies investigating the endocrinologic disturbances in this pathology are necessary ...